https://pubmed.ncbi.nlm.nih.gov/34373667/

Novel Non-Opioid Based Therapeutics for Chronic Neuropathic Pain

Timothy M Doyle 1, Kathryn Braden 1, Caron M Harada 1, Fatma Mufti 1, Rachel M Schafer 1, Daniela Salvemini 1Affiliations expand

Free PMC article

Abstract

Chronic neuropathic pain is currently a major health issue in U.S. complicated by the lack of non-opioid analgesic alternatives. Our investigations led to the discovery of major signaling pathways involved in the transition of acute to chronic neuropathic pain and the identification of several targets for therapeutic intervention. Our translational approach has facilitated the advancement of novel medicines for chronic neuropathic pain that are in advanced clinical development and clinical trials.